Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2
نویسندگان
چکیده
Jun Wan, Aya Yamamura, Adriana M. Zimnicka, Guillaume Voiriot, Kimberly A. Smith, Haiyang Tang, Ramon J. Ayon, Moumita S. R. Choudhury, Eun A. Ko, Jun Wang, Chen Wang, Ayako Makino, and Jason X.-J. Yuan Department of Medicine, Institute for Personalized Respiratory Medicine, Department of Pharmacology, and Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, Illinois; Department of Pulmonary and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, and Beijing Institute of Respiratory Medicine, and Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing, China; Department of Physiology, Capital Medical University, Beijing, China; and Beijing Hospital of the Ministry of Health, Beijing, China
منابع مشابه
Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Cav1.2 and Cav3.2.
Hypoxia-induced pulmonary hypertension (HPH) is characterized by sustained pulmonary vasoconstriction and vascular remodeling, both of which are mediated by pulmonary artery smooth muscle cell (PASMC) contraction and proliferation, respectively. An increase in cytosolic Ca²⁺ concentration ([Ca²⁺]cyt) is a major trigger for pulmonary vasoconstriction and an important stimulus for cell proliferat...
متن کاملEnhanced contractility in pregnancy is associated with augmented TRPC3, L-type, and T-type voltage-dependent calcium channel function in rat uterine radial artery.
In pregnancy, α-adrenoceptor-mediated vasoconstriction is augmented in uterine radial arteries and is accompanied by underlying changes in smooth muscle (SM) Ca(2+) activity. This study aims to determine the Ca(2+) entry channels associated with altered vasoconstriction in pregnancy, with the hypothesis that augmented vasoconstriction involves transient receptor potential canonical type-3 (TRPC...
متن کاملCa(V)3.2 channels and the induction of negative feedback in cerebral arteries.
RATIONALE T-type (CaV3.1/CaV3.2) Ca(2+) channels are expressed in rat cerebral arterial smooth muscle. Although present, their functional significance remains uncertain with findings pointing to a variety of roles. OBJECTIVE This study tested whether CaV3.2 channels mediate a negative feedback response by triggering Ca(2+) sparks, discrete events that initiate arterial hyperpolarization by ac...
متن کاملCaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia.
Chronic intermittent hypoxia (CIH) is a hallmark manifestation of sleep apnea. A heightened carotid body activity and the resulting chemosensory reflex mediate increased sympathetic nerve activity by CIH. However, the mechanisms underlying heightened carotid body activity by CIH are not known. An elevation of intracellular calcium ion concentration ([Ca(2+)]i) in glomus cells, the primary oxyge...
متن کاملChronic hypoxia in pregnancy affected vascular tone of renal interlobar arteries in the offspring
Hypoxia during pregnancy could affect development of fetuses as well as cardiovascular systems in the offspring. This study was the first to demonstrate the influence and related mechanisms of prenatal hypoxia (PH) on renal interlobar arteries (RIA) in the 5-month-old male rat offspring. Following chronic hypoxia during pregnancy, phenylephrine induced significantly higher pressor responses and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013